Influence of physical exercise and relationship with biochemical variables of NT-pro-brain natriuretic peptide and ischemia modified albumin

What Was Tested

Researchers studied BNP (Nesiritide) in this controlled clinical trial publication.

The diagnostic approach and the clinical management of patients presenting with suspected acute coronary syndrome or cardiac dysfunction are as yet challenging.

Although ischemia modified albumin (IMA) and natriuretic peptides were recently proposed for detection of myocardial ischemia and cardiac dysfunction, little information is available on preanalytical and metabolic sources of variability of these markers.

Who Took Part

The abstract describes 35 individuals taking part.

PubMed indexes the participants as adults, men only.

To establish the influence of a regular endurance training and the relationship with conventional biochemical variables, NT-pro-brain natriuretic peptide (NT-proBNP) and IMA were assayed, along with cardiac troponin T (cTnT), lactate dehydrogenase (LDH), creatine kinase (CK), creatinine and albumin, in 35 sedentary healthy individuals and 50 male professional road cyclists, 12-24 h following the last demanding training session.

What Was Measured

The subject headings attached to it are Albumins, Exercise, Ischemia, Natriuretic Peptide, Brain, Nerve Tissue Proteins and Protein Precursors.

What This Means in Plain Language

This is a controlled clinical trial of BNP (Nesiritide) in 35 individuals.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2006 (Clinica chimica acta; international journal of clinical chemistry), a journal based in Netherlands.

More context: the BNP (Nesiritide) compound page, all human trials.