Left bundle branch block in chronic heart failure-impact on diastolic function, filling pressures, and B-type natriuretic peptide levels

What Was Tested

The paper reports a study of BNP (Nesiritide), published as a controlled clinical trial.

In this patient population, the researchers attempted to define the impact of LBBB on diastolic function, filling pressures, and brain natriuretic peptide and its circulating N-terminal precursor (NT-proBNP) levels.

Who Took Part

The study group was 94 patients.

PubMed indexes the participants as middle-aged adults, both men and women.

A total of 94 patients with stable CHF (48 with complete LBBB, 46 without intraventricular conduction delay and normal QRS duration) underwent conventional 2-dimensional/Doppler echocardiography and Doppler tissue analysis of mitral annular velocities.

How the Study Was Run

As a measure of left ventricular filling pressures, the ratio of peak early mitral flow velocity to peak early diastolic mitral annular velocity was derived.

What Was Measured

In this patient population, the researchers attempted to define the impact of LBBB on diastolic function, filling pressures, and brain natriuretic peptide and its circulating N-terminal precursor (NT-proBNP) levels.

Topics PubMed links to this paper include Blood Pressure, Bundle-Branch Block, Heart Failure, Natriuretic Peptide, Brain, Stroke Volume, Ultrasonography and Ventricular Dysfunction, Left.

What This Means in Plain Language

This is a controlled clinical trial of BNP (Nesiritide) in 94 patients.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2006 (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography), a journal based in United States.

More context: the BNP (Nesiritide) compound page, all human trials.