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The atypical antipsychotics olanzapine and quetiapine, but not haloperidol, reduce ACTH and cortisol secretion in healthy subjects
Plain-language guide to PMID 16432682 (2006): double-blind randomized controlled trial study of ACTH (Corticotropin).
Key Facts
- PMID
- 16432682
- Journal
- Psychopharmacology
- Year
- 2006
- Study type
- Randomized Controlled Trial
- Authors
- Cohrs S et al. (8 authors)
- DOI
- 10.1007/s00213-005-0279-x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of ACTH (Corticotropin), published as a randomized controlled trial.
Therefore, this double-blind, placebo-controlled, randomized cross-over study investigated the influence of the atypical antipsychotics quetiapine and olanzapine in comparison with haloperidol and placebo on plasma adrenocorticotropic hormone (ACTH), cortisol, and prolactin levels.
Blood samples were taken at hourly intervals from 0900 until 1700 hours.
No effect of haloperidol on AUC of ACTH or cortisol levels was observed.
Why It Was Studied
Despite the usefulness of atypical antipsychotics in the treatment of depression and their positive influence on cognitive functioning possibly related to their impact on cortisol, little is known about their effect on HPA axis function.
Who Took Part
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
Because people in this ACTH (Corticotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received ACTH (Corticotropin).
The comparison arm used a placebo, so changes seen with ACTH (Corticotropin) could be set against what happens without it.
Each person switched between ACTH (Corticotropin) and the comparison at some point, usually with a gap in between.
What Was Measured
PubMed files the paper under topics including Adrenocorticotropic Hormone, Antipsychotic Agents, Benzodiazepines, Dibenzothiazepines, Haloperidol, Hydrocortisone and Hypothalamo-Hypophyseal System.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ACTH (Corticotropin).
The publication is from 2006 (Psychopharmacology), a journal based in Germany.
More context: the ACTH (Corticotropin) compound page, all human trials.
Our Notes on the Compound
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.