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Frequency and prophylaxis of upper gastrointestinal hemorrhage in critically ill children: a prospective study comparing the efficacy of almagate, ranitidine, and sucralfate. The Gastrointestinal Hemorrhage Study Group.
Plain-language guide to PMID 1643886 (1992): randomized controlled trial of Ranitidine and Sucralfate in 165 patients.
Key Facts
- PMID
- 1643886
- Journal
- Critical care medicine
- Year
- 1992
- Study type
- Randomized Controlled Trial
- Authors
- López-Herce J et al. (6 authors)
- DOI
- 10.1097/00003246-199208000-00003
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Ranitidine and Sucralfate.
Who Took Part
According to the abstract, 165 patients were involved.
By PubMed's age tags, the people studied were children.
Twenty-five patients were excluded because of protocol violations.
A total of 140 patients completed the study, with 35 patients in each group.
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this Ranitidine study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Pediatric ICU of a tertiary care pediatric hospital.
Patients received no treatment in the control group.
Gastric pH and macroscopic bleeding were determined every 2 hrs in all patients until the end of the study.
Macroscopic bleeding was classified as nonhemorrhage, slight, or important.
Microscopic gastric bleeding was researched with guaiac testing in 72 patients (680 samples).
What Was Measured
The severity of illness was evaluated by using the Therapeutic Intervention Scoring System, Physiologic Stability Index, and the Multiorgan System Failure scores.
The risk of upper gastrointestinal hemorrhage was evaluated by the Zinner and Tryba indices, and was modified for children.
The subject headings attached to it are Aluminum Hydroxide, Antacids, Carbonates, Chi-Square Distribution, Critical Illness, Discriminant Analysis and Drug Evaluation.
What This Means in Plain Language
The paper is a randomized study of Ranitidine and Sucralfate in 165 patients.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 1992 (Critical care medicine), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.