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Serum inhibin A, VEGF and TNFalpha levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trial.
Plain-language guide to PMID 16439507 (2006): randomized controlled trial of Chorionic Gonadotropin.
Key Facts
- PMID
- 16439507
- Journal
- Human reproduction (Oxford, England)
- Year
- 2006
- Study type
- Randomized Controlled Trial
- Authors
- Babayof R et al. (9 authors)
- DOI
- 10.1093/humrep/dei475
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Chorionic Gonadotropin, published as a randomized controlled trial.
The researchers aimed to examine the serum levels of inhibin A, vascular endothelial growth factor (VEGF), tumour necrosis factor alpha (TNFalpha), estradiol (E2) and progesterone levels after triggering of final oocyte maturation with GnRH agonist compared with HCG in patients with polycystic ovaries (PCO) and to investigate the relationship between these markers and ovarian hyperstimulation syndrome (OHSS).
Who Took Part
The age groups tagged for this paper are adults, women only.
Twenty-eight patients with PCO, undergoing controlled ovarian hyperstimulation with FSH and GnRH antagonist for IVF-embryo transfer treatment, were randomized for triggering of final oocyte maturation with GnRH agonist (GnRH agonist group, n = 15) or HCG (HCG group, n = 13).
How the Study Was Run
The design is described as randomized.
The participants were allocated by chance, so the Chorionic Gonadotropin group and the comparison group should start out alike.
Blood samples were obtained on the day of randomization and thereafter every 2-7 days.
Serum levels of inhibin A, VEGF, TNFalpha, E2 and progesterone, the incidence of OHSS, ovarian size and pelvic fluid accumulation were evaluated.
What Was Measured
Topics PubMed links to this paper include Biomarkers, Chorionic Gonadotropin, Estradiol, Fertilization in Vitro, Follicle Stimulating Hormone, Gonadotropin-Releasing Hormone and Inhibins.
What This Means in Plain Language
The paper is a randomized study of Chorionic Gonadotropin.
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2006 (Human reproduction (Oxford, England)), a journal based in England.
More context: the related hCG (human chorionic gonadotropin) library page, all human trials.
Related Library Page
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.