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Zinc supplementation to HIV-1-infected pregnant women: effects on maternal anthropometry, viral load, and early mother-to-child transmission.
Plain-language guide to PMID 16452912 (2006): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 100 women.
Key Facts
- PMID
- 16452912
- Journal
- European journal of clinical nutrition
- Year
- 2006
- Study type
- Randomized Controlled Trial
- Authors
- Villamor E et al. (8 authors)
- DOI
- 10.1038/sj.ejcn.1602391
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
To examine the effect of zinc supplementation to HIV-1-infected pregnant women on viral load, early mother-to-child transmission of HIV (MTCT), and wasting.
Who Took Part
The study group was 100 women.
The age groups tagged for this paper are adults, women only.
Four hundred HIV-1-infected pregnant women.
Viral load was assessed in a random sample of 100 women at baseline and at the end of the study.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the women and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
Double-blind placebo-controlled randomized clinical trial.
Antenatal clinic in Dar es Salaam, Tanzania.
HIV status of the babies was assessed at birth and at 6 weeks postpartum.
What Was Measured
PubMed files the paper under topics including Anthropometry, HIV Infections, HIV-1, Infectious Disease Transmission, Vertical, Pregnancy Complications, Infectious, Pregnancy Outcome and Tanzania.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 100 women.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2006 (European journal of clinical nutrition), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.