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Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso
Plain-language guide to PMID 16473451 (2006): clinical trial study of Glutathione in 23 subjects, cellulite.
Key Facts
- PMID
- 16473451
- Journal
- Toxicology
- Year
- 2006
- Study type
- Clinical Trial
- Authors
- Lavergne SN et al. (8 authors)
- DOI
- 10.1016/j.tox.2006.01.018
What This Study Did, in Plain Language
What Was Tested
This clinical trial paper looks at Glutathione in the context of cellulite.
Leukocytes from patients with SMX hypersensitivity show enhanced cytotoxicity from SMX metabolites in vitro; this finding has been attributed to a possible "detoxification defect" in some individuals.
Who Took Part
The study group was 23 subjects.
The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.
What Was Measured
The subject headings attached to it are Antioxidants, Ascorbic Acid, Cell Separation, Cyclic N-Oxides, Drug Hypersensitivity, Glutathione and HIV Infections.
What This Means in Plain Language
This is a clinical trial of Glutathione in 23 subjects in people with cellulite.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2006 (Toxicology), a journal based in Ireland.
More context: the Glutathione compound page, Cellulite research.
Our Notes on the Compound
Glutathione: The body's main antioxidant.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.