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Clinical review: The rationale for banning human chorionic gonadotropin and estrogen blockers in sport.
Plain-language guide to PMID 16478815 (2006): review of hCG (human chorionic gonadotropin).
Key Facts
- PMID
- 16478815
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2006
- Study type
- Review
- Authors
- Handelsman DJ
- DOI
- 10.1210/jc.2005-2569
What This Paper Covers, in Plain Language
What It Covers
The paper reports a study of hCG (human chorionic gonadotropin), published as a review.
The objective of the study was to review the rationale underlying the banning of human chorionic gonadotropin (hCG) and estrogen blockers (antiestrogens, specific estrogen receptor modulators, aromatase inhibitors) in sports for male and female athletes in the light of gender differences in regulation of reproductive physiology.
Why It Was Studied
The researchers reviewed well-controlled clinical studies of exogenous testosterone effects on human muscle size and strength in men and all available evidence relevant to the effects of hCG and estrogen blockers on blood testosterone in men and women.
In men, there is unequivocal evidence that hCG and estrogen blockers cause consistent and sustained rise in blood testosterone concentrations.
Who the Included Studies Covered
PubMed tags the participants as both men and women.
What Was Measured
The researchers reviewed well-controlled clinical studies of exogenous testosterone effects on human muscle size and strength in men and all available evidence relevant to the effects of hCG and estrogen blockers on blood testosterone in men and women.
In men, there is unequivocal evidence that hCG and estrogen blockers cause consistent and sustained rise in blood testosterone concentrations.
PubMed files the paper under topics including Chorionic Gonadotropin, Doping in Sports, Estrogen Antagonists, Muscle, Skeletal, Selective Estrogen Receptor Modulators, Sex Characteristics and Testosterone.
What This Means in Plain Language
This is a review of hCG (human chorionic gonadotropin).
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2006 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the hCG (human chorionic gonadotropin) compound page, all human trials.
Our Notes on the Compound
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.