Intrauterine pressure, ischemia markers, and experienced pain during administration of a vasopressin V1a receptor antagonist in spontaneous and vasopressin-induced dysmenorrhea

What Was Tested

This randomized controlled trial paper looks at Vasopressin.

A model to study the effect of vasopressin V1a antagonist in dysmenorrhea.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

Eight patients with primary dysmenorrhea and eight tuballigated, healthy subjects participated on days 1-2 of two consecutive menstruations.

Intrauterine pressure was measured as area under the curve throughout the experiments.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.

Neither the participants nor the staff measuring them knew who was on Vasopressin, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.

Each person switched between Vasopressin and the comparison at some point, usually with a gap in between.

A double-blind, randomized, placebo-controlled, cross-over trial was performed.

Ischemia markers in plasma and pain recorded by a visual analog scale were measured before and after each vasopressin injection as well as before and after the start of either atosiban or placebo infusion.

What Was Measured

Topics PubMed links to this paper include Antidiuretic Hormone Receptor Antagonists, Area Under Curve, Biomarkers, Dysmenorrhea, Hormone Antagonists, Ischemia and Pain Measurement.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vasopressin.

Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2006 (Acta obstetricia et gynecologica Scandinavica), a journal based in United States.

More context: the Vasopressin compound page, all human trials.