Plasma corticotrophin releasing factor and vasopressin responses to exercise in normal man

What Was Tested

The paper reports a study of ACTH (Corticotropin) and Vasopressin, published as a randomized controlled trial.

To evaluate the hypothalamo-pituitary-adrenal (HPA) response to both mild and intense exercise.

Who Took Part

By PubMed's age tags, the people studied were adults, men only.

Subjects were exercised over a 5-minute period to the required level of intensity, which was maintained for a further 10 minutes.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got ACTH (Corticotropin) and who got the comparison, which limits bias.

Maximum oxygen consumption (VO2max.) was initially determined.

Brachial vein blood was sampled before and at 5-minute intervals during and after exercise and assayed for plasma cortisol, ACTH, arginine vasopressin (AVP), corticotrophin releasing factor (CRF), sodium and lactate levels.

Haemoglobin and haematocrit were measured before and at the end of exercise.

Heart rate was monitored continuously and blood pressure measured whenever blood was sampled before and after exercise.

What Was Measured

PubMed files the paper under topics including Adrenocorticotropic Hormone, Arginine Vasopressin, Blood Pressure, Corticotropin-Releasing Hormone, Exercise, Lactates and Lactic Acid.

What This Means in Plain Language

The paper is a randomized study of ACTH (Corticotropin) and Vasopressin.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1991 (Clinical endocrinology), a journal based in England.

More context: the ACTH (Corticotropin) compound page and the Vasopressin compound page, all human trials.