The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men

What Was Tested

The paper reports a study of GIP (Gastric Inhibitory Polypeptide), published as a clinical trial.

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) both play a role in the control of glucose homeostasis, and GIP is implicated in the regulation of energy storage.

The capacity of carbohydrates to induce secretion of these incretin hormones could be one of the factors determining the metabolic quality of different types of carbohydrates.

Who Took Part

The study group was 7 men.

The age groups tagged for this paper are adults, women only.

How the Study Was Run

In design terms this was a crossover study.

In the crossover set-up each of the men took both GIP (Gastric Inhibitory Polypeptide) and the comparison in turn, acting as their own control.

What Was Measured

The researchers analyzed the correlation between the rate of intestinal absorption of (starch-derived) glucose and plasma concentrations of GLP-1 and GIP after ingestion of glucose and starchy foods with a different content of rapidly and slowly available glucose.

All test meals were naturally labeled with 13C.

Topics PubMed links to this paper include Area Under Curve, Dietary Carbohydrates, Gastric Emptying, Gastric Inhibitory Polypeptide, Glucagon-Like Peptide 1, Glucose and Homeostasis.

What This Means in Plain Language

The paper is a crossover study of GIP (Gastric Inhibitory Polypeptide) in 7 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2006 (The Journal of nutrition), a journal based in United States.

More context: the GIP (Gastric Inhibitory Polypeptide) compound page, all human trials.