A prospective randomized study comparing misoprostol and oxytocin for premature rupture of membranes at term

What Was Tested

This randomized controlled trial paper looks at Oxytocin.

Who Took Part

The age groups tagged for this paper are adults, women only.

Ninety-seven women with PROM at term were assigned randomly to receive intravaginal misoprostol or oxytocin.

Secondary outcomes included the number of women who delivered vaginally within 12 hours of the start of the induction in the two groups, the cesarean, hyperstimulation, and failed induction rates, the mode of delivery, and the neonatal outcome.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Oxytocin and who got the comparison, which limits bias.

The primary outcome measure was the induction-delivery interval.

What Was Measured

Topics PubMed links to this paper include Administration, Intravaginal, Cesarean Section, Delivery, Obstetric, Premature Rupture of Fetal Membranes, Gestational Age, Labor, Induced and Misoprostol.

What This Means in Plain Language

The paper is a randomized study of Oxytocin.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2006 (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians), a journal based in England.

More context: the Oxytocin compound page, all human trials.