← Human Trials & Peer-Reviewed Studies
Potassium magnesium supplementation for four weeks improves small distal artery compliance and reduces blood pressure in patients with essential hypertension.
Plain-language guide to PMID 16820345 (2006): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 133 patients, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 16820345
- Journal
- Clinical and experimental hypertension (New York, N.Y. : 1993)
- Year
- 2006
- Study type
- Randomized Controlled Trial
- Authors
- Wu G et al. (6 authors)
- DOI
- 10.1080/10641960600798705
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension, published as a randomized controlled trial.
It has been postulated that the loss of arterial compliance may precede cardiovascular diseases, and that arterial compliance is an important parameter to consider when evaluating arterial diseases such as essential hypertension (EH) and the effects of antihypertensive treatment.
Who Took Part
According to the abstract, 133 patients were involved.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
In all, 133 EH patients and 147 healthy subjects were enrolled in this study.
How the Study Was Run
The design is described as randomized.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Large arterial compliance (C1) and small arterial compliance (C2) were measured by the CVProfilor DO-2020 CardioVascular Profiling System.
Before and after the four weeks, blood pressure, C1, and C2 were measured.
What Was Measured
It has been postulated that the loss of arterial compliance may precede cardiovascular diseases, and that arterial compliance is an important parameter to consider when evaluating arterial diseases such as essential hypertension (EH) and the effects of antihypertensive treatment.
PubMed files the paper under topics including Antihypertensive Agents, Arteries, Biomarkers, Blood Pressure, Case-Control Studies, Dietary Supplements and Dihydropyridines.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 133 patients in people with low blood pressure and orthostatic hypotension.
The publication is from 2006 (Clinical and experimental hypertension (New York, N.Y. : 1993)), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
- Low blood pressure and orthostatic hypotension research
- Vitamin D, K2, Magnesium and Zinc in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.