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Measurement of vitamin D status: background, clinical use, and methodologies.
Plain-language guide to PMID 16955631 (2006): review of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 16955631
- Journal
- Clinical laboratory
- Year
- 2006
- Study type
- Review
- Authors
- Hart GR et al. (4 authors)
What This Paper Covers, in Plain Language
What It Covers
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a review.
Vitamin D and its metabolites are crucial to the overall health and well-being of humans and animals, having important functions in calcium homeostasis and bone metabolism.
Exposure of the skin to sunlight may provide adequate levels of vitamin D; however, there are numerous reports of vitamin D insufficiency or deficiency. 25-hydroxyvitamin D (calcidiol, 25(OH)D) is regarded as the best measurement of overall vitamin D status. 1,25-dihydroxyvitamin D (calcitriol, 1,25(OH)2D) is the most biologically active vitamin D metabolite. 25(OH)D has higher affinity for vitamin D binding protein (VDBP) than 1,25-dihydroxyvitamin D; whereas, 1,25-dihydroxyvitamin D has higher affinity for the vitamin D receptor (VDR) than 25-hydroxyvitamin D.
What Was Measured
Exposure of the skin to sunlight may provide adequate levels of vitamin D; however, there are numerous reports of vitamin D insufficiency or deficiency. 25-hydroxyvitamin D (calcidiol, 25(OH)D) is regarded as the best measurement of overall vitamin D status. 1,25-dihydroxyvitamin D (calcitriol, 1,25(OH)2D) is the most biologically active vitamin D metabolite. 25(OH)D has higher affinity for vitamin D binding protein (VDBP) than 1,25-dihydroxyvitamin D; whereas, 1,25-dihydroxyvitamin D has higher affinity for the vitamin D receptor (VDR) than 25-hydroxyvitamin D.
HPLC and immunoassays allow the determination of vitamin D status, as measured by 25(OH)D, and 1,25(OH)2D.
Topics PubMed links to this paper include Calcifediol, Calcitriol, Chemistry Techniques, Analytical, Chromatography, High Pressure Liquid, Health Status, Immunoassay and Vitamin D.
What This Means in Plain Language
This is a review of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2006 (Clinical laboratory), a journal based in Germany.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.