Effect of right ventricular apex pacing on the Tei index and brain natriuretic peptide in patients with a dual-chamber pacemaker

What Was Tested

This controlled clinical trial paper looks at BNP (Nesiritide).

The aim of this study was to characterize the effects of RVA pacing on LV and RV function by assessing isovolumic contraction time and isovolumic relaxation time divided by ejection time (Tei index) and by assessing changes in plasma brain natriuretic peptide (BNP).

Why It Was Studied

Asynchronous electrical activation induced by right ventricular apex (RVA) pacing can cause various abnormalities in left ventricular (LV) function, particularly in the context of severe LV dysfunction or structural heart disease.

However, the effect of RVA pacing in patients with normal LV and right ventricular (RV) function has not been fully elucidated.

Who Took Part

The abstract describes 76 patients taking part.

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

Doppler echocardiographic study and BNP measurements were performed at follow-up (mean intervals from pacemaker implantation, 44+/-75 months) in 76 patients with dual chamber pacemakers (sick sinus syndrome, n=30; atrioventricular block, n=46) without structural heart disease.

What Was Measured

The subject headings attached to it are Cardiac Pacing, Artificial, Equipment Failure, Health Status Indicators, Natriuretic Peptide, Brain, Pacemaker, Artificial, Stroke Volume and Ventricular Dysfunction, Left.

What This Means in Plain Language

This is a controlled clinical trial of BNP (Nesiritide) in 76 patients.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2006 (Pacing and clinical electrophysiology : PACE), a journal based in United States.

More context: the BNP (Nesiritide) compound page, all human trials.