In vivo effects of corticotropin-releasing hormone on femoral adipose tissue metabolism in women

What Was Tested

This randomized controlled trial paper looks at ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

Twelve healthy normal weight female volunteers (age 20-37 years, body mass index: 22.75+/-1.33 kg/m(2)).

Assessment of local generation of glycerol, and glucose in adipose tissue by microdialysis.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and crossover.

The participants were allocated by chance, so the ACTH (Corticotropin) group and the comparison group should start out alike.

As a double-blind ACTH (Corticotropin) study, the assignments were hidden from both participants and investigators until the end.

Some participants received a placebo instead of ACTH (Corticotropin), giving a reference point.

Each person switched between ACTH (Corticotropin) and the comparison at some point, usually with a gap in between.

Measurement of adipose tissue and skin blood flow by laser Doppler flowmetry.

What Was Measured

PubMed files the paper under topics including Adipose Tissue, Blood Glucose, Corticotropin-Releasing Hormone, Fatty Acids, Nonesterified, Glucose, Glycerol and Microdialysis.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2007 (International journal of obesity (2005)), a journal based in England.

More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.