The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition

What Was Tested

This randomized controlled trial paper looks at Ghrelin.

To clarify the role of nutrients in the control of ghrelin secretion evaluating the effects of intravenous and oral lipids and aminoacids compared with glucose and fructose load in healthy subjects.

Why It Was Studied

The nutritional control of ghrelin has not been fully clarified yet.

Particularly, the influence of aminoacids and lipids is controversial and, moreover, whether the intraluminal gastric contact with nutrients is required or if the modulatory action of nutrients on ghrelin secretion is mediated by insulin is still matter of debate.

Who Took Part

The age groups tagged for this paper are adults, men only.

How the Study Was Run

In design terms this was a randomized and crossover study.

Because people in this Ghrelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Each person switched between Ghrelin and the comparison at some point, usually with a gap in between.

Total ghrelin, insulin, and glucose were assayed every 15 min from 0 up to +180 min.

What Was Measured

The subject headings attached to it are Amino Acids, Area Under Curve, Blood Glucose, Dietary Carbohydrates, Dietary Fats, Enteral Nutrition and Fat Emulsions, Intravenous.

What This Means in Plain Language

The paper is a randomized and crossover study of Ghrelin.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2006 (European journal of nutrition), a journal based in Germany.

More context: the Ghrelin compound page, all human trials.