The effects of nicotine on the metabolic and hormonal responses during acute cold exposure.

What Was Tested

Researchers studied Therapeutic nicotine (patch, non-peptide) in this randomized controlled trial publication.

To examine the effects of nicotine on the metabolic and hormonal responses during acute cold exposure.

Who Took Part

According to the abstract, 6 men were involved.

By PubMed's age tags, the people studied were adults, both men and women.

Participants in this study included 6 men and 5 women between the ages of 19 and 25 years.

Each subject performed 2 cold-air trials (CATs) consisting of a 30-minute baseline (BASE) period and a 120-minute exposure to 10 degree C air.

How the Study Was Run

The researchers set it up as a randomized, placebo-controlled and crossover study.

The men were allocated by chance, so the Therapeutic nicotine (patch, non-peptide) group and the comparison group should start out alike.

Some men received a placebo instead of Therapeutic nicotine (patch, non-peptide), giving a reference point.

Each person switched between Therapeutic nicotine (patch, non-peptide) and the comparison at some point, usually with a gap in between.

Blood samples for metabolic and hormonal measurements were obtained at the end of BASE and immediately after the cold exposure.

What Was Measured

PubMed files the paper under topics including Area Under Curve, Blood Glucose, Body Temperature Regulation, Cold Temperature, Fatty Acids, Nonesterified, Glycerol and Hormones.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Therapeutic nicotine (patch, non-peptide) in 6 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2006 (Wilderness & environmental medicine), a journal based in United States.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.