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Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety
Plain-language guide to PMID 17092365 (2006): single-blind randomized controlled trial study of Peptide YY and Ghrelin.
Key Facts
- PMID
- 17092365
- Journal
- The British journal of nutrition
- Year
- 2006
- Study type
- Randomized Controlled Trial
- Authors
- Weickert MO et al. (7 authors)
- DOI
- 10.1017/bjn20061902
What This Study Did, in Plain Language
What Was Tested
Researchers studied Peptide YY and Ghrelin in this randomized controlled trial publication.
Because nutrient-induced changes of 'satiety hormones' from the gut may play a role in this process, the researchers evaluated the effects of purified insoluble fibres on postprandial responses of plasma peptide YY (PYY), serum ghrelin and satiety as secondary outcome measures of a study investigating effects of cereal fibres on parameters of glucose metabolism.
After 24 h run-in periods and 10 h overnight fasts, subjects ingested isoenergetic and macronutrient matched portions of control white bread or fibre-enriched bread (wheat-fibre or oat-fibre) at 08.15 hours.
Who Took Part
PubMed tags the participants as women only.
How the Study Was Run
The design is described as randomized, single-blind and crossover.
Because people in this Peptide YY study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Only one side, usually the participants, was kept unaware of whether Peptide YY was given.
Each person switched between Peptide YY and the comparison at some point, usually with a gap in between.
Gut hormones and hunger scores were measured for 300 min.
What Was Measured
Because nutrient-induced changes of 'satiety hormones' from the gut may play a role in this process, the researchers evaluated the effects of purified insoluble fibres on postprandial responses of plasma peptide YY (PYY), serum ghrelin and satiety as secondary outcome measures of a study investigating effects of cereal fibres on parameters of glucose metabolism.
PubMed files the paper under topics including Avena, Bread, Dietary Fiber, Ghrelin, Hunger, Peptide Hormones and Peptide YY.
What This Means in Plain Language
The paper is a randomized, single-blind and crossover study of Peptide YY and Ghrelin.
The publication is from 2006 (The British journal of nutrition), a journal based in England.
More context: the Peptide YY compound page and the Ghrelin compound page, all human trials.
Our Notes on the Compounds
Peptide YY: A 36-amino-acid gut hormone released after eating that is studied for its role in appetite.
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.