[Effects of xinshuai mistura on plasma angiotensin II, atrial natriuretic peptide and N terminal pro-brain natriuretic peptide in patients with heart failure]

Plain-language guide to PMID 17121038 (2006): single-blind randomized controlled trial study of BNP (Nesiritide) and ANP (Atrial Natriuretic Peptide).

Key Facts

PMID: 17121038
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Year: 2006
Study type: Randomized Controlled Trial
Authors: Dai M et al. (3 authors)

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of BNP (Nesiritide) and ANP (Atrial Natriuretic Peptide), published as a randomized controlled trial.

To observe the effects of Xinshuai Mistura (XM) on plasma angiotensin II (Ang II), atrial natriuretic peptide (ANP) and N terminal pro- brain natriuretic peptide (Nt-proBNP) in patients with heart failure (HF).

Who Took Part

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

Fifty-nine patients with HF (NYHA class II-IV) were randomly divided into two groups, the treated group treated with XM and the control group with Wuling Pulvis (WP), both on the base of captopril treatment.

The treatment course was two weeks.

How the Study Was Run

The design is described as randomized and single-blind.

Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Only one side, usually the participants, was kept unaware of whether BNP (Nesiritide) was given.

Plasma levels of Ang II , ANP and Nt-proBNP were observed.

What Was Measured

The subject headings attached to it are Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Atrial Natriuretic Factor, Captopril, Drugs, Chinese Herbal, Heart Failure and Natriuretic Peptide, Brain.

What This Means in Plain Language

The paper is a randomized and single-blind study of BNP (Nesiritide) and ANP (Atrial Natriuretic Peptide).

Its findings take up roughly 2 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2006 (Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine), a journal based in China.

More context: the BNP (Nesiritide) compound page and the ANP (Atrial Natriuretic Peptide) compound page, all human trials.

Our Notes on the Compounds

BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.

ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.

Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.