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Effect of CCK-1 receptor blockade on ghrelin and PYY secretion in men
Plain-language guide to PMID 17138722 (2007): double-blind randomized controlled trial study of Ghrelin and Cholecystokinin (CCK) in 12 subjects.
Key Facts
- PMID
- 17138722
- Journal
- American journal of physiology. Regulatory, integrative and comparative physiology
- Year
- 2007
- Study type
- Randomized Controlled Trial
- Authors
- Degen L et al. (8 authors)
- DOI
- 10.1152/ajpregu.00734.2006
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Ghrelin and Cholecystokinin (CCK).
The aim of this study was therefore to investigate whether CCK mediated the effect of intraduodenal (ID) fat on ghrelin secretion and PYY release via CCK-1 receptors.
Why It Was Studied
Cholecystokinin (CCK), peptide YY (PYY), and ghrelin have been proposed to act as satiety hormones.
CCK and PYY are stimulated during meal intake by the presence of nutrients in the small intestine, especially fat, whereas ghrelin is inhibited by eating.
Who Took Part
The study group was 12 subjects.
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
Random assignment meant chance, not the researchers, decided who got Ghrelin and who got the comparison, which limits bias.
Neither the subjects nor the staff measuring them knew who was on Ghrelin, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Ghrelin group a baseline to be compared against.
In the crossover set-up each of the subjects took both Ghrelin and the comparison in turn, acting as their own control.
ID infusions were given for 180 min.
Plasma hormone concentrations were measured in regular intervals by specific RIA systems.
What Was Measured
CCK and PYY are stimulated during meal intake by the presence of nutrients in the small intestine, especially fat, whereas ghrelin is inhibited by eating.
The subject headings attached to it are Caprylates, Cholecystokinin, Enzyme Inhibitors, Fatty Acids, Ghrelin, Lactones and Lipase.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Ghrelin and Cholecystokinin (CCK) in 12 subjects.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2007 (American journal of physiology. Regulatory, integrative and comparative physiology), a journal based in United States.
More context: the Ghrelin compound page and the Cholecystokinin (CCK) compound page, all human trials.
Our Notes on the Compounds
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Cholecystokinin (CCK): A gut and brain peptide hormone that stimulates gallbladder contraction and signals fullness.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.