The effect of growth hormone on the response of total and acylated ghrelin to a standardized oral glucose load and insulin resistance in children with Prader-Willi syndrome

What Was Tested

The paper reports a study of Ghrelin in the context of insulin resistance, prediabetes & type 2 diabetes, published as a clinical trial.

The researchers investigated the influence of GH on acylated (aGhr) and total ghrelin (tGhr) concentrations before and after an oral glucose load, and on insulin resistance in PWS children.

Why It Was Studied

Fasting levels of plasma ghrelins are grossly elevated in children with Prader-Willi syndrome (PWS).

The cause of this elevation and the regulation of ghrelins in PWS is largely unknown.

Who Took Part

The abstract describes 28 children taking part.

PubMed indexes the participants as young children, children and teenagers, both men and women.

The study was conducted in a single center (University Children's Hospital).

What Was Measured

Fasting levels of plasma ghrelins are grossly elevated in children with Prader-Willi syndrome (PWS).

The subject headings attached to it are Acylation, Blood Glucose, Ghrelin, Glucose Tolerance Test, Growth Hormone, Insulin Resistance and Peptide Hormones.

What This Means in Plain Language

This is a clinical trial of Ghrelin in 28 children in people with insulin resistance, prediabetes & type 2 diabetes.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2007 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Ghrelin compound page, Insulin resistance, prediabetes & type 2 diabetes research.