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The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults.
Plain-language guide to PMID 17277040 (2007): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 314 adults.
Key Facts
- PMID
- 17277040
- Journal
- Diabetes care
- Year
- 2007
- Study type
- Randomized Controlled Trial
- Authors
- Pittas AG et al. (4 authors)
- DOI
- 10.2337/dc06-1994
- Registered trial
- NCT00357643
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The researchers sought to compare the effects of combined calcium and vitamin D supplementation versus placebo on blood glucose and markers of inflammation in nondiabetic adults aged > or =65 years.
Who Took Part
The study group was 314 adults.
PubMed indexes the participants as older adults, both men and women.
In a post hoc analysis, fasting plasma glucose (FPG), insulin sensitivity (estimated by homeostasis model assessment of insulin resistance [HOMA-IR]), plasma C-reactive protein, and interleukin-6, were measured at baseline and 3 years.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
What Was Measured
PubMed files the paper under topics including Biomarkers, Blood Glucose, Body Mass Index, Calcium, Dietary, Dietary Supplements, Hyperglycemia and Inflammation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 314 adults.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2007 (Diabetes care), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.