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ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects.
Plain-language guide to PMID 17298881 (2007): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc, osteoporosis and bone density.
Key Facts
- PMID
- 17298881
- Journal
- The Journal of steroid biochemistry and molecular biology
- Year
- 2007
- Study type
- Randomized Controlled Trial
- Authors
- Matsumoto T et al. (2 authors)
- DOI
- 10.1016/j.jsbmb.2006.12.088
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of osteoporosis and bone density in this randomized controlled trial publication.
In order to address this issue, the researchers performed post hoc analysis to compare the effect of ED-71 on lumbar and hip BMD between subjects with upper (>29 ng/mL) and lower tertiles (<25 ng/mL) of serum 25(OH)D.
Why It Was Studied
These effects on BMD were stronger than any previous results using 1alpha(OH)D3 or 1,25(OH)2D3.
However, there still was a concern that the effect of ED-71 could be observed because serum 25(OH)D in many of these subjects were below its optimal level.
Who Took Part
PubMed tags the participants as women only.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
However, there still was a concern that the effect of ED-71 could be observed because serum 25(OH)D in many of these subjects were below its optimal level.
Topics PubMed links to this paper include Bone Density, Calcitriol, Hip Joint, Lumbar Vertebrae, Osteoporosis and Vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in people with osteoporosis and bone density.
The publication is from 2007 (The Journal of steroid biochemistry and molecular biology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Osteoporosis and bone density research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.