Leuprolide acetate-prepared in vitro fertilization-gamete intrafallopian transfer cycles: efficacy versus controls and cost analysis

Plain-language guide to PMID 1740205 (1992): randomized controlled trial study of HMG (Human Menopausal Gonadotropin) and Leuprolide.

Key Facts

PMID: 1740205
Journal: Fertility and sterility
Year: 1992
Study type: Randomized Controlled Trial
Authors: Corson SL et al. (6 authors)
DOI: 10.1016/s0015-0282(16)54907-3

What This Study Did, in Plain Language

What Was Tested

Researchers studied HMG (Human Menopausal Gonadotropin) and Leuprolide in this randomized controlled trial publication.

To evaluate the effect of gonadotropin-releasing hormone agonist (GnRH-a) when given through stimulation with gonadotropins versus stopping it as stimulation was initiated versus a control group unprepared in this manner.

Also, to construct a cost analysis for this type of therapy in an in vitro fertilization-gamete intrafallopian transfer program (IVF-GIFT).

Who Took Part

The age groups tagged for this paper are adults, women only.

One hundred new patients entering an IVF-GIFT program.

How the Study Was Run

The design is described as randomized.

The participants were allocated by chance, so the HMG (Human Menopausal Gonadotropin) group and the comparison group should start out alike.

Prospective, consecutive, randomized, with a control group.

In vitro fertilization or GIFT cycles with or without preparation (pituitary suppression) by GnRH-a administration in which suppression was continued or halted as gonadotropins were begun.

What Was Measured

PubMed files the paper under topics including Costs and Cost Analysis, Fertilization in Vitro, Gamete Intrafallopian Transfer, Gonadotropin-Releasing Hormone, Menotropins, Probability and Reproductive Techniques.

What This Means in Plain Language

The paper is a randomized study of HMG (Human Menopausal Gonadotropin) and Leuprolide.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1992 (Fertility and sterility), a journal based in United States.

More context: the HMG (Human Menopausal Gonadotropin) compound page and the Leuprolide compound page, all human trials.

Our Notes on the Compounds

HMG (Human Menopausal Gonadotropin): Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.

Leuprolide: A 9-amino-acid GnRH analog (Lupron, Eligard) that lowers sex-hormone levels with ongoing use; used in prostate cancer, endometriosis and early puberty.

Triptorelin: A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.