Influence of corticotropin-releasing hormone on gastric sensitivity and motor function in healthy volunteers

What Was Tested

This randomized controlled trial paper looks at ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).

As stress may be involved in the generation of functional dyspeptic symptoms, the researchers evaluated the effect of the stress hormone, corticotropin-releasing hormone, on proximal stomach function.

Twelve healthy volunteers [six women; 23 years (20-26 years)] underwent a barostat study on 2 days.

Who Took Part

By PubMed's age tags, the people studied were adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and crossover study.

Random assignment meant chance, not the researchers, decided who got ACTH (Corticotropin) and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received ACTH (Corticotropin).

In the crossover set-up each of the participants took both ACTH (Corticotropin) and the comparison in turn, acting as their own control.

What Was Measured

As stress may be involved in the generation of functional dyspeptic symptoms, the researchers evaluated the effect of the stress hormone, corticotropin-releasing hormone, on proximal stomach function.

PubMed files the paper under topics including Blood Pressure, Corticotropin-Releasing Hormone, Dyspepsia, Gastric Emptying, Gastric Fundus, Heart Rate and Hydrocortisone.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2007 (European journal of gastroenterology & hepatology), a journal based in England.

More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.