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Magnesium supplementation and perinatal hypoxia: outcome of a parallel group randomised trial in pregnancy.
Plain-language guide to PMID 17578470 (2007): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 4494 women.
Key Facts
- PMID
- 17578470
- Journal
- BJOG : an international journal of obstetrics and gynaecology
- Year
- 2007
- Study type
- Randomized Controlled Trial
- Authors
- Harrison V et al. (3 authors)
- DOI
- 10.1111/j.1471-0528.2007.01409.x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
To determine the effects of magnesium supplementation in pregnancy on the incidence of hypoxic-ischaemic encephalopathy (HIE).
Why It Was Studied
A group of 4494 black pregnant women of low socio-economic status.
Who Took Part
The study group was 4494 women.
PubMed indexes the participants as teenagers, adults and middle-aged adults, women only.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and pilot.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
A randomised double-blind placebo-controlled study.
A Midwife Obstetric Unit and its two referral hospitals in Cape Town, South Africa.
What Was Measured
PubMed files the paper under topics including Apgar Score, Arrhythmias, Cardiac, Dietary Supplements, Fetal Heart, Hypoxia-Ischemia, Brain, Meconium Aspiration Syndrome and Pilot Projects.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 4494 women.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2007 (BJOG : an international journal of obstetrics and gynaecology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.