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Effect of oxytocics on the blood pressure of normotensive Nigerian parturients
Plain-language guide to PMID 17701671 (2007): double-blind randomized controlled trial study of Oxytocin, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 17701671
- Journal
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Year
- 2007
- Study type
- Randomized Controlled Trial
- Authors
- Jago AA et al. (4 authors)
- DOI
- 10.1080/14767050701500406
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Oxytocin in the context of low blood pressure and orthostatic hypotension, published as a randomized controlled trial.
To evaluate the effect of ergometrine and oxytocin on the cardiovascular system when used for active management of the third stage of labor.
Why It Was Studied
However, the adverse effects of these oxytocic agents, in particular ergometrine, have not been properly evaluated in their environment.
Who Took Part
PubMed tags the participants as women only.
How the Study Was Run
The researchers set it up as a randomized and double-blind study.
Random assignment meant chance, not the researchers, decided who got Oxytocin and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received Oxytocin.
The timeline in the abstract includes 24 months.
A double-blind, randomized controlled study was carried out at the Federal Medical Centre, Makurdi over 24 months.
Their effects on the cardiovascular system were observed using blood pressure as a marker.
What Was Measured
However, the adverse effects of these oxytocic agents, in particular ergometrine, have not been properly evaluated in their environment.
Topics PubMed links to this paper include Blood Pressure, Ergonovine, Labor Stage, Third, Nigeria, Oxytocics, Oxytocin and Parturition.
What This Means in Plain Language
The paper is a randomized and double-blind study of Oxytocin in people with low blood pressure and orthostatic hypotension over 24 months.
The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2007 (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians), a journal based in England.
More context: the Oxytocin compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.