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Atrial natriuretic peptide serum concentration decreases in donors undergoing discontinuous plasmapheresis involving a large extracorporeal blood volume
Plain-language guide to PMID 17725739 (2007): randomized controlled trial study of ANP (Atrial Natriuretic Peptide).
Key Facts
- PMID
- 17725739
- Journal
- Transfusion
- Year
- 2007
- Study type
- Randomized Controlled Trial
- Authors
- Karger R et al. (5 authors)
- DOI
- 10.1111/j.1537-2995.2007.01347.x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ANP (Atrial Natriuretic Peptide).
It was the aim of this study to delineate whether atrial natriuretic peptide (ANP) is involved in the BV regulation of plasmapheresis donors.
Why It Was Studied
In donor plasmapheresis, circulatory reactions occur at a similar frequency as in whole-blood donation although the large extracorporeal blood volume (ECV) occurring during discontinuous plasmapheresis might predispose donors to hypovolemic reactions.
The regulatory mechanisms compensating for this intradonation blood volume (BV) deficit are not well understood.
Who Took Part
PubMed tags the participants as both men and women.
How the Study Was Run
The researchers set it up as a randomized study.
The participants were allocated by chance, so the ANP (Atrial Natriuretic Peptide) group and the comparison group should start out alike.
ANP serum concentrations were determined in 60 donors undergoing discontinuous plasmapheresis.
Samples were taken before the start of the procedure and when maximum ECV (ECV(max)) was reached at the end of the last withdrawal.
Donors were randomly selected after stratification for sex and BV.
In a control investigation, the same donors were kept in a reclined position for the duration of a plasmapheresis session without plasma withdrawal.
ANP plasma concentration changes were correlated with changes of hemodynamic variables, which were recorded noninvasively with bioelectrical impedance cardiography.
What Was Measured
PubMed files the paper under topics including Atrial Natriuretic Factor, Blood Donors, Blood Volume and Plasmapheresis.
What This Means in Plain Language
The paper is a randomized study of ANP (Atrial Natriuretic Peptide).
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2007 (Transfusion), a journal based in United States.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.