Parental preference of prandial insulin aspart compared with preprandial human insulin in a basal-bolus scheme with NPH insulin in a 12-wk crossover study of preschool children with type 1 diabetes

What Was Tested

The paper reports a study of Insulin Aspart and NPH Insulin (isophane), published as a randomized controlled trial.

Preprandial insulin injection in preschool children is complicated by irregular eating habits.

Who Took Part

The abstract describes 26 children taking part.

By PubMed's age tags, the people studied were young children.

This study is a randomized, 12-wk, crossover trial comparing IAsp and regular HI in 26 children (17 boys and 9 girls; age: 2.4-6.9 yr).

Treatment satisfaction was assessed by a modified version of the WHO Diabetes Treatment Satisfaction Questionnaire (DTSQ-M).

How the Study Was Run

In design terms this was a randomized and crossover study.

Random assignment meant chance, not the researchers, decided who got Insulin Aspart and who got the comparison, which limits bias.

Each person switched between Insulin Aspart and the comparison at some point, usually with a gap in between.

Regular HI was injected 30 min before and IAsp after or shortly before meals.

What Was Measured

PubMed files the paper under topics including Blood Glucose, Diabetes Mellitus, Type 1, Eating, Hypoglycemic Agents, Insulin, Insulin Aspart and Insulin, Isophane.

What This Means in Plain Language

The paper is a randomized and crossover study of Insulin Aspart and NPH Insulin (isophane) in 26 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2007 (Pediatric diabetes), a journal based in China.

More context: the Insulin Aspart compound page and the NPH Insulin (isophane) compound page.