Overnight testing of renal concentrating capacity in children using desmopressin tablets: sensitivity, repeatability and non-inferiority versus intranasal spray

What Was Tested

This randomized controlled trial paper looks at Vasopressin and Desmopressin.

The purpose of this trial was to investigate whether a renal concentrating capacity test with desmopressin could be performed with oral tablets instead of the previously used nasal spray.

Who Took Part

The study group was 154 children.

By PubMed's age tags, the people studied were young children and children, both men and women.

A total of 154 children aged 3-18 years, who were candidates for a renal concentrating capacity test, were included in a randomized, double-dummy, crossover trial.

How the Study Was Run

The researchers set it up as a randomized, placebo-controlled and crossover study.

The children were allocated by chance, so the Vasopressin group and the comparison group should start out alike.

Some children received a placebo instead of Vasopressin, giving a reference point.

Each person switched between Vasopressin and the comparison at some point, usually with a gap in between.

What Was Measured

The subject headings attached to it are Antidiuretic Agents, Deamino Arginine Vasopressin, Kidney Concentrating Ability, Kidney Function Tests, Osmolar Concentration, Reproducibility of Results and Sensitivity and Specificity.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Vasopressin and Desmopressin in 154 children.

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2008 (Scandinavian journal of urology and nephrology), a journal based in England.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.