Vitamin D supplementation has minor effects on parathyroid hormone and bone turnover markers in vitamin D-deficient bedridden older patients

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this randomized controlled trial publication.

To evaluate the effects of vitamin D supplementation on parathyroid function and bone turnover in aged, chronically immobile patients.

Who Took Part

The age groups tagged for this paper are older adults and people over 80, both men and women.

Two hundred and eighteen long-term inpatients aged over 65 years.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Because people in this Parathyroid Hormone (PTH 1-84) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Parathyroid Hormone (PTH 1-84), so expectations could not easily colour the readings.

A randomised double-blind controlled trial.

Plasma concentrations of 25-hydroxyvitamin D (25-OHD), intact parathyroid hormone (PTH), amino-terminal propeptide of type I procollagen (PINP), a marker of bone formation, and carboxy-terminal telopeptide of type I collagen (ICTP), a marker of bone resorption, were measured at baseline and after 6 months.

What Was Measured

Topics PubMed links to this paper include Bed Rest, Bone Density, Calcium, Cholecalciferol, Collagen Type I, Long-Term Care and Parathyroid Hormone.

What This Means in Plain Language

The paper is a randomized and double-blind study of Parathyroid Hormone (PTH 1-84).

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2008 (Age and ageing), a journal based in England.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.