Effect of annual intramuscular vitamin D on fracture risk in elderly men and women--a population-based, randomized, double-blind, placebo-controlled trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Low trauma fractures in older people incur enormous physical, social and economic costs.

This strategy requires validation in a population setting.

Who Took Part

The abstract describes 9440 people taking part.

The age groups tagged for this paper are older adults and people over 80, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The people were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Primary outcome measure was all non-vertebral fracture.

Secondary outcomes were hip and wrist fractures, and all falls.

What Was Measured

Topics PubMed links to this paper include Bone Density, Ergocalciferols, Fractures, Spontaneous, Geriatric Assessment, Incidence, Osteoporosis and Probability.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 9440 people.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2007 (Rheumatology (Oxford, England)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.