A high-fat diet raises fasting plasma CCK but does not affect upper gut motility, PYY, and ghrelin, or energy intake during CCK-8 infusion in lean men

What Was Tested

This randomized controlled trial looks at Ghrelin and Cholecystokinin (CCK).

There is evidence from studies in animals that the effects of both fat and CCK on gastrointestinal function and energy intake are attenuated by consumption of a high-fat diet.

In humans, the effects of exogenous CCK-8 on antropyloroduodenal motility, plasma CCK, peptide YY (PYY), and ghrelin concentrations, appetite, and energy intake are attenuated by a high-fat diet.

Who Took Part

The age groups tagged for this paper are teenagers and adults, men only.

How the Study Was Run

In design terms this was a randomized, single-blind and crossover study.

Random assignment meant chance, not the researchers, decided who got Ghrelin and who got the comparison, which limits bias.

Only one side, usually the participants, was kept unaware of whether Ghrelin was given.

In the crossover set-up each of the participants took both Ghrelin and the comparison in turn, acting as their own control.

What Was Measured

There is evidence from studies in animals that the effects of both fat and CCK on gastrointestinal function and energy intake are attenuated by consumption of a high-fat diet.

PubMed files the paper under topics including Cholecystokinin, Dietary Fats, Duodenum, Energy Intake, Fasting, Gastrointestinal Motility and Ghrelin.

What This Means in Plain Language

The paper is a randomized, single-blind and crossover study of Ghrelin and Cholecystokinin (CCK).

The publication is from 2008 (American journal of physiology. Regulatory, integrative and comparative physiology), a journal based in United States.

More context: the Ghrelin compound page and the Cholecystokinin (CCK) compound page, all human trials.