Differential responses of circulating amylin to high-fat vs. high-carbohydrate meal in healthy men

What Was Tested

Researchers studied Amylin (Islet Amyloid Polypeptide) in this randomized controlled trial publication.

The success of an amylin analogue in weight loss trials has generated interest in amylin as a physiological satiety signal.

Little is known about how plasma amylin responds to macronutrients.

This study examined the effects of a high-carbohydrate meal (CHO), a high-fat meal (FAT) or a continued fast (FAST) on amylin concentrations and correlations among other satiety hormones and measures of appetite.

Who Took Part

By PubMed's age tags, the people studied were adults, men only.

In a randomized, crossover design, 10 healthy males consumed a meal high in carbohydrate or fat or continued fasted.

Blood samples and subjective hunger scores were obtained at baseline and 30, 90 and 210 min postprandial.

How the Study Was Run

The researchers set it up as a randomized and crossover study.

Random assignment meant chance, not the researchers, decided who got Amylin (Islet Amyloid Polypeptide) and who got the comparison, which limits bias.

In the crossover set-up each of the participants took both Amylin (Islet Amyloid Polypeptide) and the comparison in turn, acting as their own control.

What Was Measured

Topics PubMed links to this paper include Amyloid, Area Under Curve, Blood Glucose, C-Peptide, Dietary Carbohydrates, Dietary Fats and Ghrelin.

What This Means in Plain Language

The paper is a randomized and crossover study of Amylin (Islet Amyloid Polypeptide).

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2008 (Clinical endocrinology), a journal based in England.

More context: the Amylin (Islet Amyloid Polypeptide) compound page, all human trials.