Acute effects of ghrelin administration on glucose and lipid metabolism

What Was Tested

This randomized controlled trial paper looks at Ghrelin.

Their objective was to study direct effects of ghrelin on substrate metabolism.

Who Took Part

By PubMed's age tags, the people studied were adults, men only.

Eight healthy men aged 27.2 +/- 0.9 yr with a body mass index of 23.4 +/- 0.5 kg/m(2) were included in the study.

How the Study Was Run

The researchers set it up as a randomized, single-blind, placebo-controlled and crossover study.

Because people in this Ghrelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Only one side, usually the participants, was kept unaware of whether Ghrelin was given.

Some participants received a placebo instead of Ghrelin, giving a reference point.

In the crossover set-up each of the participants took both Ghrelin and the comparison in turn, acting as their own control.

This was a randomized, single-blind, placebo-controlled two-period crossover study.

The study was performed in a university clinical research laboratory.

A hyperinsulinemic (0.6 mU x kg(-1) x min(-1)) euglycemic clamp was performed during the final 2 h of each infusion.

What Was Measured

The subject headings attached to it are Blood Glucose, Calorimetry, Indirect, Energy Metabolism, Fatty Acids, Nonesterified, Ghrelin, Glucagon and Glucose.

What This Means in Plain Language

The paper is a randomized, single-blind and placebo-controlled study of Ghrelin.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2008 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Ghrelin compound page, all human trials.