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The effect of a highly specific serotonin agonist on osmoregulated vasopressin secretion in healthy man
Plain-language guide to PMID 1814657 (1991): double-blind randomized controlled trial study of Vasopressin.
Key Facts
- PMID
- 1814657
- Journal
- Clinical endocrinology
- Year
- 1991
- Study type
- Randomized Controlled Trial
- Authors
- Faull CM et al. (3 authors)
- DOI
- 10.1111/j.1365-2265.1991.tb03560.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vasopressin, published as a randomized controlled trial.
To explore a possible interaction of the serotonin neurotransmitter system and posterior pituitary function, the researchers have looked at the effect of fluoxetine treatment on osmoregulated vasopressin secretion in normal men in two placebo controlled studies.
Who Took Part
The age groups tagged for this paper are teenagers and adults, men only.
On the 8th day subjects underwent assessment.
In Study 2 the relationship of plasma vasopressin to change in plasma osmolality was calculated for each subject by linear regression analysis.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The participants were allocated by chance, so the Vasopressin group and the comparison group should start out alike.
Blinding on both sides kept the participants and researchers unaware of who received Vasopressin.
The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.
Study 1, 9; Study 2, 10.
In both studies regular measures of plasma osmolality, sodium and vasopressin were made.
In Study 1 urine osmolality was measured together with urine volume at set time points and an accumulative measure of percentage of water load excreted.
Free water clearance was calculated.
What Was Measured
PubMed files the paper under topics including Body Water, Fluoxetine, Osmolar Concentration, Sodium, Urine, Vasopressins and Water-Electrolyte Balance.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vasopressin.
Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 1991 (Clinical endocrinology), a journal based in England.
More context: the Vasopressin compound page, all human trials.
Our Notes on the Compound
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.