← Human Trials & Peer-Reviewed Studies
Vasopressin and oxytocin do not influence early sensory processing but affect mood and activation in man
Plain-language guide to PMID 1815225 (1991): double-blind and placebo-controlled controlled clinical trial study of Oxytocin and Vasopressin in 12 volunteers.
Key Facts
- PMID
- 1815225
- Journal
- Peptides
- Year
- 1991
- Study type
- Controlled Clinical Trial
- Authors
- Pietrowsky R et al. (5 authors)
- DOI
- 10.1016/0196-9781(91)90224-d
What This Study Did, in Plain Language
What Was Tested
This controlled clinical trial paper looks at Oxytocin and Vasopressin.
Effects of arginine-vasopressin (AVP) and oxytocin (OX) on brainstem and middle latency auditory-evoked potentials (BAEP and MAEP), reflecting early sensory processing within the specific auditory pathways and primary auditory cortex, were investigated.
Additionally, subjects rated their feelings of activation and mood on an adjective check list (EWL).
Who Took Part
The study group was 12 volunteers.
PubMed indexes the participants as adults, men only.
How the Study Was Run
The design is described as double-blind and placebo-controlled.
Neither the volunteers nor the staff measuring them knew who was on Oxytocin, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Oxytocin group a baseline to be compared against.
What Was Measured
Effects of arginine-vasopressin (AVP) and oxytocin (OX) on brainstem and middle latency auditory-evoked potentials (BAEP and MAEP), reflecting early sensory processing within the specific auditory pathways and primary auditory cortex, were investigated.
The subject headings attached to it are Affect, Arginine Vasopressin, Arousal, Central Nervous System, Evoked Potentials, Auditory, Evoked Potentials, Auditory, Brain Stem and Neural Pathways.
What This Means in Plain Language
The paper is a double-blind and placebo-controlled study of Oxytocin and Vasopressin in 12 volunteers.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1991 (Peptides), a journal based in United States.
More context: the Oxytocin compound page and the Vasopressin compound page, all human trials.
Our Notes on the Compounds
Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.