← Human Trials & Peer-Reviewed Studies
Relationship between morning hypertension identified by home blood pressure monitoring and brain natriuretic peptide and estimated glomerular filtration rate: the Japan Morning Surge 1 (JMS-1) Study
Plain-language guide to PMID 18174769 (2008): randomized controlled trial study of BNP (Nesiritide) in 611 patients, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 18174769
- Journal
- Journal of clinical hypertension (Greenwich, Conn.)
- Year
- 2008
- Study type
- Randomized Controlled Trial
- Authors
- Ishikawa J et al. (10 authors)
- DOI
- 10.1111/j.1524-6175.2007.07250.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of BNP (Nesiritide) in the context of low blood pressure and orthostatic hypotension, published as a randomized controlled trial.
The researchers evaluated whether morning minus evening systolic blood pressure (SBP) difference (MEdif) in home blood pressure measurements can be a marker for hypertensive target organ damage.
The authors analyzed 611 hypertensive patients who had high morning SBP levels (>/=135 mm Hg).
Who Took Part
The study group was 611 patients.
The age groups tagged for this paper are adults, middle-aged adults, older adults and people over 80, both men and women.
How the Study Was Run
The design is described as randomized.
Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
The researchers evaluated whether morning minus evening systolic blood pressure (SBP) difference (MEdif) in home blood pressure measurements can be a marker for hypertensive target organ damage.
The authors analyzed 611 hypertensive patients who had high morning SBP levels (>/=135 mm Hg).
The subject headings attached to it are Blood Pressure Monitoring, Ambulatory, Circadian Rhythm, Glomerular Filtration Rate, Hypertension, Hypertrophy, Left Ventricular, Natriuretic Peptide, Brain and Systole.
What This Means in Plain Language
The paper is a randomized study of BNP (Nesiritide) in 611 patients in people with low blood pressure and orthostatic hypotension.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2008 (Journal of clinical hypertension (Greenwich, Conn.)), a journal based in United States.
More context: the BNP (Nesiritide) compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.