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Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide
Plain-language guide to PMID 18243612 (2008): double-blind randomized controlled trial study of ANP (Atrial Natriuretic Peptide) in 12 men.
Key Facts
- PMID
- 18243612
- Journal
- Journal of ethnopharmacology
- Year
- 2008
- Study type
- Randomized Controlled Trial
- Authors
- Ai P et al. (6 authors)
- DOI
- 10.1016/j.jep.2007.12.005
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ANP (Atrial Natriuretic Peptide).
To evaluate its diuretic/natriuretic effect, the researchers conducted a double-blind, randomized, crossover study in 12 healthy men.
Why It Was Studied
The diuretic effect of Astragali Radix (AR) in humans was described in ancient books, but its mechanism has not been identified.
ARE elevated plasma ANP (pANP), urinary excretion of cGMP (U(cGMP)V) and U(cGMP)V/pANP ratio without affecting plasma level of rennin-angiotensin-aldosterone system, mean arterial blood pressure and glomerular filtration rate.
Who Took Part
The abstract describes 12 men taking part.
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
The men were allocated by chance, so the ANP (Atrial Natriuretic Peptide) group and the comparison group should start out alike.
Blinding on both sides kept the men and researchers unaware of who received ANP (Atrial Natriuretic Peptide).
A placebo (an inactive look-alike) gave the ANP (Atrial Natriuretic Peptide) group a baseline to be compared against.
Each person switched between ANP (Atrial Natriuretic Peptide) and the comparison at some point, usually with a gap in between.
What Was Measured
ARE elevated plasma ANP (pANP), urinary excretion of cGMP (U(cGMP)V) and U(cGMP)V/pANP ratio without affecting plasma level of rennin-angiotensin-aldosterone system, mean arterial blood pressure and glomerular filtration rate.
The subject headings attached to it are Astragalus propinquus, Atrial Natriuretic Factor, Creatinine, Cyclic GMP, Electrolytes, Kidney and Natriuresis.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ANP (Atrial Natriuretic Peptide) in 12 men.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2008 (Journal of ethnopharmacology), a journal based in Ireland.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.