Mannitol stimulates atrial natriuretic peptide release in humans

What Was Tested

The paper reports a study of ANP (Atrial Natriuretic Peptide), published as a randomized controlled trial.

The purpose of this study was to determine if mannitol stimulates atrial natriuretic peptide (ANP) release in humans and to examine potential mechanisms for this effect.

Why It Was Studied

All measurements were made at three time points: at baseline, at 10 minutes (after the bolus but before radiocontrast administration), and at 60 minutes (after completion of the study).

Baseline plasma ANP (PANP) measurements (mean +/- SE) were similar in both groups (saline, 73 +/- 38 pg/mL; mannitol, 62 +/- 11 pg/mL).

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this ANP (Atrial Natriuretic Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

All measurements were made at three time points: at baseline, at 10 minutes (after the bolus but before radiocontrast administration), and at 60 minutes (after completion of the study).

Baseline plasma ANP (PANP) measurements (mean +/- SE) were similar in both groups (saline, 73 +/- 38 pg/mL; mannitol, 62 +/- 11 pg/mL).

The subject headings attached to it are Atrial Natriuretic Factor, Cardiac Catheterization, Diuresis, Kidney, Mannitol, Osmolar Concentration and Sodium Chloride.

What This Means in Plain Language

The paper is a randomized study of ANP (Atrial Natriuretic Peptide).

The publication is from 1991 (American journal of kidney diseases : the official journal of the National Kidney Foundation), a journal based in United States.

More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.