Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation

What Was Tested

Researchers studied DMSO (dimethyl sulfoxide, non-peptide solvent) in the context of rosacea in this randomized controlled trial publication.

Who Took Part

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

Forty-six patients affected by stage I-III rosacea entered this double-blind, placebo-controlled study.

Subjects were treated for 1 month.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Because people in this DMSO (dimethyl sulfoxide, non-peptide solvent) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received DMSO (dimethyl sulfoxide, non-peptide solvent).

A placebo (an inactive look-alike) gave the DMSO (dimethyl sulfoxide, non-peptide solvent) group a baseline to be compared against.

The methods mention a period of 1 month.

Clinical and instrumental evaluations were done at baseline, after 10 and 20 days, and at the end of the study.

Itching, stinging, erythema, and papules were investigated clinically as well as hydration and erythema instrumentally with capacitance and color measurements.

What Was Measured

Topics PubMed links to this paper include Administration, Cutaneous, Analysis of Variance, Anti-Inflammatory Agents, Antioxidants, Dimethyl Sulfoxide, Rosacea and Silymarin.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of DMSO (dimethyl sulfoxide, non-peptide solvent) in people with rosacea over 1 month.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2008 (Journal of cosmetic dermatology), a journal based in England.

More context: the DMSO (dimethyl sulfoxide, non-peptide solvent) compound page, Rosacea research.