← Human Trials & Peer-Reviewed Studies
A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial.
Plain-language guide to PMID 18279523 (2008): double-blind randomized controlled trial of Glucosamine.
Key Facts
- PMID
- 18279523
- Journal
- Nutrition journal
- Year
- 2008
- Study type
- Randomized Controlled Trial
- Authors
- Frestedt JL et al. (4 authors)
- DOI
- 10.1186/1475-2891-7-9
- Registered trial
- NCT00452101
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Glucosamine, published as a randomized controlled trial.
This small, pilot study evaluated the impact of treatment with a natural multi-mineral supplement from seaweed (Aquamin) on walking distance, pain and joint mobility in subjects with moderate to severe osteoarthritis of the knee.
Who Took Part
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and pilot.
The participants were allocated by chance, so the Glucosamine group and the comparison group should start out alike.
Blinding on both sides kept the participants and researchers unaware of who received Glucosamine.
The comparison arm used a placebo, so changes seen with Glucosamine could be set against what happens without it.
It is described as a pilot, a small early test of whether a larger Glucosamine study would be practical.
Primary outcome measures were WOMAC scores and 6 Minute Walking Distances (6 MWD).
Laboratory based blood tests were used as safety measures.
What Was Measured
This small, pilot study evaluated the impact of treatment with a natural multi-mineral supplement from seaweed (Aquamin) on walking distance, pain and joint mobility in subjects with moderate to severe osteoarthritis of the knee.
PubMed files the paper under topics including Analysis of Variance, Dietary Supplements, Glucosamine, Minerals, Osteoarthritis, Knee, Pain Measurement and Pilot Projects.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Glucosamine.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2008 (Nutrition journal), a journal based in England.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.