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A prospective crossover study comparing secretin-stimulated endoscopic and Dreiling tube pancreatic function testing in patients evaluated for chronic pancreatitis
Plain-language guide to PMID 18294508 (2008): crossover randomized controlled trial study of Secretin.
Key Facts
- PMID
- 18294508
- Journal
- Gastrointestinal endoscopy
- Year
- 2008
- Study type
- Randomized Controlled Trial
- Authors
- Stevens T et al. (7 authors)
- DOI
- 10.1016/j.gie.2007.07.028
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Secretin.
Their aim was to compare the bicarbonate results obtained from the secretin ePFT and Dreiling PFT methods in patients evaluated for chronic pancreatitis.
A prospective crossover design was used to compare the PFT methods.
Why It Was Studied
Direct pancreatic function tests (PFT) are conventionally performed with use of double-lumen "Dreiling" collection tubes.
The researchers have developed an endoscopic collection method (ePFT) that eases the performance of these tests.
Who Took Part
PubMed indexes the participants as middle-aged adults, both men and women.
Twenty-four patients undergoing an evaluation for chronic pancreatitis underwent the secretin-stimulated ePFT and Dreiling PFT methods on separate days.
How the Study Was Run
The design is described as randomized and crossover.
Because people in this Secretin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Each person switched between Secretin and the comparison at some point, usually with a gap in between.
What Was Measured
Direct pancreatic function tests (PFT) are conventionally performed with use of double-lumen "Dreiling" collection tubes.
The researchers have developed an endoscopic collection method (ePFT) that eases the performance of these tests.
The subject headings attached to it are Bicarbonates, Duodenum, Endoscopy, Gastrointestinal, Gastrointestinal Agents, Intestinal Secretions, Intubation, Gastrointestinal and Pancreatic Function Tests.
What This Means in Plain Language
The paper is a randomized and crossover study of Secretin.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2008 (Gastrointestinal endoscopy), a journal based in United States.
More context: the Secretin compound page, all human trials.
Our Notes on the Compound
Secretin: A 27-amino-acid gut hormone that triggers pancreatic secretion; used as a diagnostic agent in pancreatic function testing.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.