The MUSCAT study: a Multicenter PROBE Study Comparing the Effects of Angiotensin II Type-1 Receptor Blockers on Self-Monitored Home Blood Pressure in Patients with Morning Hypertension: study design and background characteristics.

Plain-language guide to PMID 18360018 (2008): double-blind randomized controlled trial of Angiotensin II Type 1 Receptor Blockers in 1,234 patients, low blood pressure and orthostatic hypotension.

Key Facts

PMID: 18360018
Journal: Hypertension research : official journal of the Japanese Society of Hypertension
Year: 2008
Study type: Randomized Controlled Trial
Authors: Uchida H et al. (6 authors)
DOI: 10.1291/hypres.31.51

What This Study Did, in Plain Language

What Was Tested

Researchers studied Angiotensin II Type 1 Receptor Blockers in the context of low blood pressure and orthostatic hypotension in this randomized controlled trial publication.

Elevated morning home blood pressure (MHBP) has been reported to have a close relationship to cerebro-cardiovascular events and hypertensive target organ damages, and hence is regarded as a predictor of cardiovascular events.

In recent guidelines, angiotensin II type-1 receptor blockers (ARBs) are recommended as the first-choice drugs for antihypertensive therapy.

Who Took Part

According to the abstract, 1,234 patients were involved.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized and double-blind study.

The patients were allocated by chance, so the Angiotensin II Type 1 Receptor Blockers group and the comparison group should start out alike.

As a double-blind Angiotensin II Type 1 Receptor Blockers study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

PubMed files the paper under topics including Angiotensin II Type 1 Receptor Blockers, Blood Pressure, Blood Pressure Determination, Blood Pressure Monitoring, Ambulatory, Cardiovascular Diseases, Data Interpretation, Statistical and Ethics.

What This Means in Plain Language

The paper is a randomized and double-blind study of Angiotensin II Type 1 Receptor Blockers in 1,234 patients in people with low blood pressure and orthostatic hypotension.

With several hundred people or more, it is a fairly large study for this kind of research.

The publication is from 2008 (Hypertension research : official journal of the Japanese Society of Hypertension), a journal based in England.

More context: Low blood pressure and orthostatic hypotension research.

Low blood pressure and orthostatic hypotension research

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.