Endometrin for luteal phase support in a randomized, controlled, open-label, prospective in-vitro fertilization trial using a combination of Menopur and Bravelle for controlled ovarian hyperstimulation

What Was Tested

Researchers studied HMG (Human Menopausal Gonadotropin) in the context of endometriosis in this randomized controlled trial publication.

Who Took Part

According to the abstract, 1,211 patients were involved.

PubMed indexes the participants as teenagers, young adults and adults, women only.

How the Study Was Run

The design is described as randomized, single-blind, open-label and multicenter.

Random assignment meant chance, not the researchers, decided who got HMG (Human Menopausal Gonadotropin) and who got the comparison, which limits bias.

In this single-blind HMG (Human Menopausal Gonadotropin) study one party knew the assignments and the other did not.

Being open-label, the HMG (Human Menopausal Gonadotropin) study did not mask who received what.

More than one site took part, so the patients came from several places.

A time span of 10 weeks appears in the methods.

Multicenter, randomized, open-label (assessor-blinded) phase III clinical trial.

In vitro fertilization and ET were performed according to site-specific protocols.

The day after oocyte retrieval, Endometrin or vaginal P(4) gel was begun for luteal support and continued for up to 10 weeks of pregnancy.

What Was Measured

Topics PubMed links to this paper include Drug Combinations, Fertility Agents, Female, Fertilization in Vitro, Intrauterine Devices, Medicated, Luteal Phase, Menotropins and Ovulation Induction.

What This Means in Plain Language

The paper is a randomized, single-blind and open-label study of HMG (Human Menopausal Gonadotropin) in 1,211 patients in people with endometriosis over 10 weeks.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2009 (Fertility and sterility), a journal based in United States.

More context: the HMG (Human Menopausal Gonadotropin) compound page, Endometriosis research.