Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study

What Was Tested

This randomized controlled trial paper looks at Peptide YY and Ghrelin.

In this prospective double blind study, the researchers aim to evaluate and compare the effects of laparoscopic Roux-en-Y gastric bypass (LRYGBP) with laparoscopic sleeve gastrectomy (LSG) on body weight, appetite, fasting, and postprandial ghrelin and peptide-YY (PYY) levels.

Who Took Part

The abstract describes 16 patients taking part.

After randomization, 16 patients were assigned to LRYGBP and 16 patients to LSG.

Patients were reevaluated on the 1st, 3rd, 6th, and 12th postoperative month.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Random assignment meant chance, not the researchers, decided who got Peptide YY and who got the comparison, which limits bias.

Neither the patients nor the staff measuring them knew who was on Peptide YY, so expectations could not easily colour the readings.

Blood samples were collected after an overnight fast and in 6 patients in each group after a standard 420 kcal mixed meal.

What Was Measured

Topics PubMed links to this paper include Appetite, Bariatric Surgery, Gastrectomy, Gastric Bypass, Ghrelin, Peptide YY and Weight Loss.

What This Means in Plain Language

The paper is a randomized and double-blind study of Peptide YY and Ghrelin in 16 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2008 (Annals of surgery), a journal based in United States.

More context: the Peptide YY compound page and the Ghrelin compound page, all human trials.