← Human Trials & Peer-Reviewed Studies
Involvement of calcitonin gene-related peptide in migraine: regional cerebral blood flow and blood flow velocity in migraine patients
Plain-language guide to PMID 18437288 (2008): double-blind randomized controlled trial study of CGRP (Calcitonin Gene-Related Peptide) in 12 patients, migraine.
Key Facts
- PMID
- 18437288
- Journal
- The journal of headache and pain
- Year
- 2008
- Study type
- Randomized Controlled Trial
- Authors
- Lassen LH et al. (7 authors)
- DOI
- 10.1007/s10194-008-0036-8
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of CGRP (Calcitonin Gene-Related Peptide) in the context of migraine, published as a randomized controlled trial.
It is therefore important to investigate its mechanism of action in patients with migraine.
Why It Was Studied
CGRP is the most potent vasodilator known in isolated cerebral blood vessels.
The researchers here investigate the effects of intravenous human alpha-CGRP (halphaCGRP) on intracranial hemodynamics.
Who Took Part
The abstract describes 12 patients taking part.
The age groups tagged for this paper are adults and middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
The patients were allocated by chance, so the CGRP (Calcitonin Gene-Related Peptide) group and the comparison group should start out alike.
Neither the patients nor the staff measuring them knew who was on CGRP (Calcitonin Gene-Related Peptide), so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the CGRP (Calcitonin Gene-Related Peptide) group a baseline to be compared against.
Each person switched between CGRP (Calcitonin Gene-Related Peptide) and the comparison at some point, usually with a gap in between.
What Was Measured
PubMed files the paper under topics including Blood Flow Velocity, Blood Pressure, Calcitonin Gene-Related Peptide, Cerebrovascular Circulation, Heart Rate, Middle Cerebral Artery and Migraine Disorders.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of CGRP (Calcitonin Gene-Related Peptide) in 12 patients in people with migraine.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2008 (The journal of headache and pain), a journal based in England.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, Migraine research.
Our Notes on the Compound
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.