← Human Trials & Peer-Reviewed Studies
Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men
Plain-language guide to PMID 18469237 (2008): double-blind randomized controlled trial study of Peptide YY and Cholecystokinin (CCK).
Key Facts
- PMID
- 18469237
- Journal
- The American journal of clinical nutrition
- Year
- 2008
- Study type
- Randomized Controlled Trial
- Authors
- Feltrin KL et al. (7 authors)
- DOI
- 10.1093/ajcn/87.5.1181
What This Study Did, in Plain Language
What Was Tested
Researchers studied Peptide YY and Cholecystokinin (CCK) in this randomized controlled trial publication.
The researchers compared the effects of equicaloric loads of C12 and C18 on antropyloroduodenal (APD) motility, plasma concentrations of cholecystokinin (CCK) and peptide YY (PYY), appetite, and energy intake.
Why It Was Studied
The regulation of gastrointestinal function and energy intake by fatty acids depends on their chain length.
Who Took Part
The age groups tagged for this paper are adults and middle-aged adults, men only.
How the Study Was Run
In design terms this was a randomized, double-blind and crossover study.
Because people in this Peptide YY study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the participants nor the staff measuring them knew who was on Peptide YY, so expectations could not easily colour the readings.
Each person switched between Peptide YY and the comparison at some point, usually with a gap in between.
Energy intake at a buffet meal was quantified.
What Was Measured
The regulation of gastrointestinal function and energy intake by fatty acids depends on their chain length.
The subject headings attached to it are Appetite, Cholecystokinin, Duodenum, Energy Intake, Gastrointestinal Motility, Infusions, Parenteral and Lauric Acids.
What This Means in Plain Language
The paper is a randomized, double-blind and crossover study of Peptide YY and Cholecystokinin (CCK).
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2008 (The American journal of clinical nutrition), a journal based in United States.
More context: the Peptide YY compound page and the Cholecystokinin (CCK) compound page, all human trials.
Our Notes on the Compounds
Peptide YY: A 36-amino-acid gut hormone released after eating that is studied for its role in appetite.
Cholecystokinin (CCK): A gut and brain peptide hormone that stimulates gallbladder contraction and signals fullness.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.