Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment

What Was Tested

This randomized controlled trial paper looks at Carnosine in the context of skin sensitivity and body aches on glp-1 medicines.

The therapeutic potential of L-carnosine and Rhodiola rosea, as antioxidant and neuromodulatory, respectively, leads them to investigate the effects of the R. rosea extract/L-carnosine-associated compound (RCAC) on sensitive skin alterations.

One perceptibility questionnaire was applied at the onset and at the end of the treatment to evaluate the subjective response to test product.

Additionally, in vitro studies were performed to investigate RCAC neuroimmunomodulatory mechanisms.

Why It Was Studied

The pathophysiology of sensitive skin consists of an inflammatory reaction resulting from the abnormal penetration in the skin of potentially irritating substances, which occurs due to skin barrier dysfunction and changes in the production of local neuromediators.

Who Took Part

According to the abstract, 124 volunteers were involved.

By PubMed's age tags, the people studied were middle-aged adults.

A double-blind comparative study was conducted on 124 volunteers with sensitive skin, who were selected by their reactivity to stinging test.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The volunteers were allocated by chance, so the Carnosine group and the comparison group should start out alike.

Neither the volunteers nor the staff measuring them knew who was on Carnosine, so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Carnosine group a baseline to be compared against.

What Was Measured

The subject headings attached to it are Administration, Cutaneous, Analysis of Variance, Antioxidants, Calcitonin Gene-Related Peptide, Carnosine, Cells, Cultured and Cytokines.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Carnosine in 124 volunteers in people with skin sensitivity and body aches on glp-1 medicines.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2008 (Journal of cosmetic dermatology), a journal based in England.

More context: the Carnosine compound page, Skin sensitivity and body aches on GLP-1 medicines research.